Southampton Women's Football Club was established in 1970, making the club the oldest and most successful women's team in Southampton, winning the Women's FA Cup eight times between 1971 and 1982.

Southampton Women's FC is now a completely renovated club with two senior sides and a flourishing youth development programme.

As Hampshire League Champions at the end of the 2015/16 season, the club was promoted to the Southern Region Premier League. The team achieved the league and cup double in the 2016/17 season and had successful cup runs in the County Cup and FA Cup.

Back to back promotion for the Firsts meant promotion to the formerly named FA Women's Premier League in 2017-18, whilst the Reserves won the Hampshire County Women's League Division 1 as undefeated champions and moved into the Southern Region. The first under-16s team were league runners-up too.

The team is their seventh season in Tier 4 now known as the FA Women’s National League Division One South West. Southampton narrowly missed out on promotion to the Southern Premier in their first two seasons in Division One South West.

In 2022 the club began a rebrand through a collaboration with Kit and Bone that started with a new badge before the launch of the “Sirens” nickname to help differentiate themselves from Southampton FC Women, “Saints”.

Their most recent honour came in April 2023 when they lifted the Southampton Divisional FA Cup winning on penalties against Eastleigh in the Community.